The clash comes after news emerged this week that Pep Guardiola has signed a new two-year extension with the club, with the boss hoping to break the four-match losing streak his side experienced before the international break.
For the Blues, John Stones and Jack Grealish return to the team, but Jérémy Doku missed due to an injury.
Meanwhile, Tottenham will be without Rodrigo Bentancur after he was charged by the FA for comments about teammate Son Heung-min.
Who will come out on top in this fascinating clash?
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